RESUMO
INTRODUCTION: Adhesion-regulating molecule 1 (ADRM1) is a polyubiquitin receptor on the 26S proteasome. ADRM1 is upregulated in many cancers. In this study, we evaluated the potential prognostic and predictive value of ADRM1 in breast cancer. MATERIALS AND METHODS: Individual and pooled survival analyses were performed on 19 independent breast cancer microarray datasets. Gene signatures enriched by ADRM1 were also analyzed in pooled datasets. RESULTS: Gene set enrichment analysis revealed that high expression of ADRM1 was significantly associated with aggressive breast cancer. Our findings revealed that ADRM1 mRNA levels were significantly associated with estrogen receptor (ER) status, progesterone receptor status, tumor size, lymph node status, histologic grade, and molecular subtypes. We also found that higher mRNA ADRM1 expression was significantly correlated with poor survival in patients with breast cancer. The prognostic power of ADRM1 mRNA was similar to the 70-gene wound response genes and 21 gene recurrence score; it was superior to TNM staging. The prognostic value of ADRM1 was better in ER-positive (ER+) breast cancer cases than in ER-negative breast cancer cases. In cases involving stage II breast cancer, radiotherapy significantly reduced the relative risk of OS in the ADRM1-low subgroup. CONCLUSION: ADRM1 mRNA levels were significantly related to poor outcome in our breast cancer sample population. It could serve as a prognostic biomarker, especially in ER+ breast cancer and Luminal A breast cancer cases, as well as a predictive biomarker for ER+ breast cancer.
Assuntos
Biomarcadores Tumorais/genética , Neoplasias da Mama/terapia , Peptídeos e Proteínas de Sinalização Intracelular/genética , Recidiva Local de Neoplasia/embriologia , Mama/patologia , Mama/cirurgia , Neoplasias da Mama/genética , Neoplasias da Mama/mortalidade , Neoplasias da Mama/patologia , Conjuntos de Dados como Assunto , Feminino , Seguimentos , Perfilação da Expressão Gênica , Regulação Neoplásica da Expressão Gênica , Humanos , Mastectomia , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/genética , Recidiva Local de Neoplasia/prevenção & controle , Estadiamento de Neoplasias , Análise de Sequência com Séries de Oligonucleotídeos , Valor Preditivo dos Testes , Prognóstico , Intervalo Livre de Progressão , RNA Mensageiro/metabolismo , Radioterapia Adjuvante , Receptores de Estrogênio/análise , Receptores de Estrogênio/metabolismo , Estudos Retrospectivos , Medição de Risco/métodosRESUMO
BACKGROUND: The objective of this study was to obtain detailed anatomical information about the lateral lymph nodes, in order to determine whether they might play a role in presacral local recurrence of rectal cancer after total mesorectal excision without lateral lymph node dissection. METHODS: Ten serially sectioned human fetal pelvises were studied at high magnification and a three-dimensional reconstruction of the fetal pelvis was made. RESULTS: Examination of the histological sections and the three-dimensional reconstruction showed that lateral lymph node tissue comprises a major proportion of the pelvic tissue volume. There were no lymph nodes located in the presacral area. Connections between the mesorectal and extramesorectal lymph node system were found in all fetal pelvises, located below the peritoneal reflection on the anterolateral side of the fetal rectum. At this site middle rectal vessels passed to and from the mesorectum, and branches of the autonomic nervous system bridge to innervate the rectal wall. CONCLUSION: The findings of this study support the hypothesis that tumour recurrence might arise from lateral lymph nodes.
Assuntos
Linfonodos/embriologia , Recidiva Local de Neoplasia/etiologia , Neoplasias Retais/etiologia , Sacro/embriologia , Humanos , Recidiva Local de Neoplasia/embriologia , Pelve/embriologia , Neoplasias Retais/embriologia , Reto/inervaçãoRESUMO
Experience of treatment of 36 patients with extramedullary spinal cord tumors is summarized. Pigmented macules, papillomas or the spinous processes painfulness while irritation were determined on skin in accordance to tumor localization in the innervation zone of one or two segments.
Assuntos
Melanoma/etiologia , Recidiva Local de Neoplasia/etiologia , Neurilemoma/etiologia , Neoplasias da Medula Espinal/etiologia , Adulto , Idoso , Terapia Combinada , Feminino , Humanos , Melanoma/embriologia , Melanoma/cirurgia , Recidiva Local de Neoplasia/embriologia , Recidiva Local de Neoplasia/cirurgia , Neurilemoma/embriologia , Neurilemoma/cirurgia , Cuidados Pós-Operatórios , Neoplasias da Medula Espinal/embriologia , Neoplasias da Medula Espinal/cirurgiaRESUMO
A reinvestigation of 171 basal cell carcinomas of the head and neck treated by surgical excision revealed 23 recurrences. Recurrence rate in one group of basal cell carcinomas, situated on embryologic fusion lines, was statistically higher than in other groups of basal cell carcinomas situated on other parts of the face and on the capillitium which served as control. Histopathologic subclassification of the recurrent basal cell carcinomas revealed a higher incidence of nodular type with infiltrative margin and of the infiltrative type. Basal cell carcinomas situated in fusion lines tended to grow deeper than in other sites. It was concluded that embryologic fusion lines in the face provide risk zones for spread and recurrence of basal cell carcinomas. Subclassification of basal cell carcinomas should be performed in the routine histopathologic reporting of these neoplasms as a means of predicting recurrence.
